Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 835356..835867 Replicon chromosome
Accession NZ_CP118060
Organism Staphylococcus haemolyticus strain VSI35

Toxin (Protein)


Gene name TsdT Uniprot ID Q4L7W7
Locus tag PUW68_RS04155 Protein ID WP_011275259.1
Coordinates 835661..835867 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag PUW68_RS04150 Protein ID WP_037538785.1
Coordinates 835356..835649 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW68_RS04125 (PUW68_04125) 830485..831276 + 792 WP_070580744.1 hydroxyethylthiazole kinase -
PUW68_RS04130 (PUW68_04130) 831278..831916 + 639 WP_070580742.1 thiamine phosphate synthase -
PUW68_RS04135 (PUW68_04135) 832005..832880 + 876 WP_070580741.1 membrane protein insertase YidC -
PUW68_RS04140 (PUW68_04140) 832944..833585 - 642 WP_275016349.1 HD domain-containing protein -
PUW68_RS04145 (PUW68_04145) 833685..835169 - 1485 WP_070678228.1 cardiolipin synthase -
PUW68_RS04150 (PUW68_04150) 835356..835649 + 294 WP_037538785.1 copper-sensing transcriptional repressor CsoR Antitoxin
PUW68_RS04155 (PUW68_04155) 835661..835867 + 207 WP_011275259.1 heavy-metal-associated domain-containing protein Toxin
PUW68_RS04160 (PUW68_04160) 835975..836112 + 138 WP_141751058.1 Lmo0850 family protein -
PUW68_RS04165 (PUW68_04165) 836161..837351 - 1191 WP_070580735.1 FtsW/RodA/SpoVE family cell cycle protein -
PUW68_RS04170 (PUW68_04170) 837769..838839 + 1071 WP_070580733.1 D-alanine--D-alanine ligase -
PUW68_RS04175 (PUW68_04175) 838855..840210 + 1356 WP_070580731.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(15-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7857.79 Da        Isoelectric Point: 4.0742

>T272731 WP_011275259.1 NZ_CP118060:835661-835867 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11236.86 Da        Isoelectric Point: 6.6364

>AT272731 WP_037538785.1 NZ_CP118060:835356-835649 [Staphylococcus haemolyticus]
MNNHENAHHSEQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1K7I8

Antitoxin

Source ID Structure

References