Detailed information of TA system TA272730

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1387820..1389252
• Replicon: chromosome
• Accession: NZ_CP118054
• Organism: Streptococcus anginosus strain VSI37

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: PUW49_RS06975
• Protein ID: WP_264338276.1
• Coordinates: 1388407..1389252 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: PUW49_RS06970
• Protein ID: WP_150867680.1
• Coordinates: 1387820..1388410 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PUW49_RS06970 (PUW49_06970)	1387820..1388410	+	591	WP_150867680.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PUW49_RS06975 (PUW49_06975)	1388407..1389252	+	846	WP_264338276.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PUW49_RS06980 (PUW49_06980)	1389349..1392135	-	2787	WP_264338278.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1373583..1429463	55880

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-259)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-51)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32556.96 Da
• Isoelectric Point: 5.1971

>T272730 WP_264338276.1 NZ_CP118054:1388407-1389252 [Streptococcus anginosus]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEAILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTADIDFLFHKQTLSEE
NIQQQLEEILTESKDGIQFSIQSITAIKESDDYGGYRATILCQLENIKQIIHLDIATGDIVTPYPATYDYKAIFDDDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKDDIDFSQLKIACERTFSYRETELDFNKIIELLERFKSDS
IQQQQWQNYSKKYSYTKDILFTDILNEIISLLIALNSNHNA

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23060.46 Da
• Isoelectric Point: 7.8326

>AT272730 WP_150867680.1 NZ_CP118054:1387820-1388410 [Streptococcus anginosus]
MSKKELLLEYLDSHNGMITYRDCKKLGIPTIYLTRLENEGVIFRVDKGIYLSSSGDYDEYYFFQYRYPRTVFSHISALYL
QGLTDEIPQYFEVTVPRDYRFRNTPLNLNIHTVSKDIVNLGVTSVKTPMGNTVNVYNFERVLCDFILNRNNIDAELFVKT
LQTYSNFPKKNLSKLYEYAQKLNILDEVKRTLEVLL

Nucleotide

• Length: 591 bp