Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1365780..1367023 | Replicon | chromosome |
| Accession | NZ_CP118054 | ||
| Organism | Streptococcus anginosus strain VSI37 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | PUW49_RS06890 | Protein ID | WP_274994102.1 |
| Coordinates | 1365780..1366547 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | PUW49_RS06895 | Protein ID | WP_003024006.1 |
| Coordinates | 1366547..1367023 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PUW49_RS06865 (PUW49_06865) | 1360810..1361169 | - | 360 | WP_150867729.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| PUW49_RS06870 (PUW49_06870) | 1361561..1362415 | - | 855 | WP_003036855.1 | hypothetical protein | - |
| PUW49_RS06875 (PUW49_06875) | 1362422..1362886 | - | 465 | WP_274994098.1 | Mov34/MPN/PAD-1 family protein | - |
| PUW49_RS06880 (PUW49_06880) | 1362864..1364630 | - | 1767 | WP_003036645.1 | ThiF family adenylyltransferase | - |
| PUW49_RS06885 (PUW49_06885) | 1364639..1365661 | - | 1023 | WP_150867728.1 | nucleotidyltransferase | - |
| PUW49_RS06890 (PUW49_06890) | 1365780..1366547 | - | 768 | WP_274994102.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| PUW49_RS06895 (PUW49_06895) | 1366547..1367023 | - | 477 | WP_003024006.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| PUW49_RS06900 (PUW49_06900) | 1367093..1367380 | - | 288 | WP_126441502.1 | hypothetical protein | - |
| PUW49_RS06905 (PUW49_06905) | 1367424..1367813 | - | 390 | WP_150867726.1 | DUF5945 family protein | - |
| PUW49_RS06910 (PUW49_06910) | 1367810..1368037 | - | 228 | WP_007520115.1 | DUF5965 family protein | - |
| PUW49_RS06915 (PUW49_06915) | 1368092..1369180 | - | 1089 | WP_150867725.1 | toprim domain-containing protein | - |
| PUW49_RS06920 (PUW49_06920) | 1369219..1369857 | - | 639 | WP_150867724.1 | peptidylprolyl isomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 29269.21 Da Isoelectric Point: 6.6139
>T272729 WP_274994102.1 NZ_CP118054:c1366547-1365780 [Streptococcus anginosus]
MRLEEFSEDEFQKALQRTIRALTRGKTIPEQPQAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEYLVDELSKQGYHLLIEGTLRTTQVPRQTAQLLRKKGYHISLAVIGTKPELSYLSTLIRYEE
LYTINPNQARATPKEHHDGIVEHLVDNLRELENDKLFDRIQIYQRDRTCIYDSETDEISAATVLQGCLFGKWSKVEEEMM
KAGTGTVERFVLEER
MRLEEFSEDEFQKALQRTIRALTRGKTIPEQPQAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEYLVDELSKQGYHLLIEGTLRTTQVPRQTAQLLRKKGYHISLAVIGTKPELSYLSTLIRYEE
LYTINPNQARATPKEHHDGIVEHLVDNLRELENDKLFDRIQIYQRDRTCIYDSETDEISAATVLQGCLFGKWSKVEEEMM
KAGTGTVERFVLEER
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18260.64 Da Isoelectric Point: 4.3971
>AT272729 WP_003024006.1 NZ_CP118054:c1367023-1366547 [Streptococcus anginosus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKMLTPLEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDTVYHRVVA
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKMLTPLEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDTVYHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|