Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2439470..2440035 Replicon chromosome
Accession NZ_CP118050
Organism Lacticaseibacillus rhamnosus strain VSI43

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag PUW66_RS11225 Protein ID WP_005692155.1
Coordinates 2439470..2439817 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PUW66_RS11230 Protein ID WP_020752297.1
Coordinates 2439817..2440035 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW66_RS11205 (PUW66_11205) 2434965..2436206 - 1242 WP_005692160.1 acyltransferase -
PUW66_RS11210 (PUW66_11210) 2436203..2436904 - 702 WP_005692159.1 ATP-binding cassette domain-containing protein -
PUW66_RS11215 (PUW66_11215) 2436897..2437715 - 819 WP_275016710.1 ABC transporter permease subunit -
PUW66_RS11220 (PUW66_11220) 2437956..2438624 - 669 WP_005692157.1 phenylalanine--tRNA ligase beta subunit-related protein -
PUW66_RS11225 (PUW66_11225) 2439470..2439817 - 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PUW66_RS11230 (PUW66_11230) 2439817..2440035 - 219 WP_020752297.1 hypothetical protein Antitoxin
PUW66_RS11235 (PUW66_11235) 2440129..2441964 - 1836 WP_015764721.1 ABC transporter ATP-binding protein -
PUW66_RS11240 (PUW66_11240) 2441951..2443741 - 1791 WP_015764722.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T272726 WP_005692155.1 NZ_CP118050:c2439817-2439470 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8117.33 Da        Isoelectric Point: 5.7995

>AT272726 WP_020752297.1 NZ_CP118050:c2440035-2439817 [Lacticaseibacillus rhamnosus]
MMDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75

Antitoxin

Source ID Structure

References