Detailed information of TA system TA272715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 316112..317349
• Replicon: chromosome
• Accession: NZ_CP118046
• Organism: Streptococcus anginosus strain VSI52

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A412PQB6
• Locus tag: PUW62_RS01655
• Protein ID: WP_007517267.1
• Coordinates: 316591..317349 (+)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: PUW62_RS01650
• Protein ID: WP_003069299.1
• Coordinates: 316112..316588 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PUW62_RS01605 (PUW62_01605)	311411..311647	+	237	WP_003069318.1	DUF5965 family protein	-
PUW62_RS01610 (PUW62_01610)	311644..312039	+	396	WP_007517275.1	DUF5945 family protein	-
PUW62_RS01615 (PUW62_01615)	312225..312506	+	282	WP_003069315.1	hypothetical protein	-
PUW62_RS01620 (PUW62_01620)	312789..312971	+	183	WP_224783947.1	hypothetical protein	-
PUW62_RS01625 (PUW62_01625)	313055..313327	-	273	Protein_284	DUF5960 family protein	-
PUW62_RS01630 (PUW62_01630)	313314..313681	-	368	Protein_285	hypothetical protein	-
PUW62_RS01635 (PUW62_01635)	313678..315083	-	1406	Protein_286	Y-family DNA polymerase	-
PUW62_RS01640 (PUW62_01640)	315088..315222	-	135	WP_003069303.1	hypothetical protein	-
PUW62_RS01645 (PUW62_01645)	315225..315917	-	693	WP_007517269.1	XRE family transcriptional regulator	-
PUW62_RS01650 (PUW62_01650)	316112..316588	+	477	WP_003069299.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
PUW62_RS01655 (PUW62_01655)	316591..317349	+	759	WP_007517267.1	type II toxin-antitoxin system toxin PezT	Toxin
PUW62_RS01660 (PUW62_01660)	317402..318688	+	1287	WP_007517265.1	SIR2 family protein	-
PUW62_RS01665 (PUW62_01665)	318681..319877	+	1197	WP_274997270.1	DUF87 domain-containing protein	-
PUW62_RS01670 (PUW62_01670)	319879..320367	+	489	WP_274997272.1	ATP-binding protein	-
PUW62_RS01675 (PUW62_01675)	320719..321081	+	363	WP_007517263.1	SAG1252 family conjugative relaxosome accessory protein	-
PUW62_RS01680 (PUW62_01680)	321084..321449	+	366	WP_007517258.1	MobC family plasmid mobilization relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 28657.64 Da
• Isoelectric Point: 6.3918

>T272715 WP_007517267.1 NZ_CP118046:316591-317349 [Streptococcus anginosus]
MIADFSTADFDLALKRTIRSLTRGKIASPEPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLALQEK
YGKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTEVPRKTAILLKSRDYQVSLALIATKPELSYLSTLIRYEEL
FAIVPNQARATPKDHHDGIVNHLVDNLRELENDQLFDYIQIYQRDRSCVYDSETDDGSAADVLQNCLLGKWSKVEKEMLK
VDQERLREMQEL

Nucleotide

• Length: 759 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18000.39 Da
• Isoelectric Point: 4.4289

>AT272715 WP_003069299.1 NZ_CP118046:316112-316588 [Streptococcus anginosus]
MIGENIKSLRKTHDLTQPEFAKIIGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGGEKMLTPVEDYQLTLKIE
VIKERGAAILAQLYRYQDSQGIAFDDETNPWILMSDDLSVQINTKIYLVDTFDEVERYNGYLDGIERMLEVASHQVVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A412PQB6