Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2043277..2043791 Replicon chromosome
Accession NZ_CP118044
Organism Staphylococcus aureus strain VSI56

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PUW46_RS09980 Protein ID WP_000581792.1
Coordinates 2043277..2043486 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PUW46_RS09985 Protein ID WP_000138932.1
Coordinates 2043498..2043791 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW46_RS09960 (PUW46_09960) 2038785..2040143 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PUW46_RS09965 (PUW46_09965) 2040158..2041228 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
PUW46_RS09970 (PUW46_09970) 2041546..2042748 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PUW46_RS09975 (PUW46_09975) 2043012..2043149 - 138 WP_000828354.1 Lmo0850 family protein -
PUW46_RS09980 (PUW46_09980) 2043277..2043486 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PUW46_RS09985 (PUW46_09985) 2043498..2043791 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PUW46_RS09990 (PUW46_09990) 2043957..2045441 + 1485 WP_000571549.1 cardiolipin synthase -
PUW46_RS09995 (PUW46_09995) 2045469..2046116 + 648 WP_001187630.1 HD domain-containing protein -
PUW46_RS10000 (PUW46_10000) 2046588..2047460 - 873 WP_000725802.1 membrane protein insertase YidC -
PUW46_RS10005 (PUW46_10005) 2047546..2048187 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T272711 WP_000581792.1 NZ_CP118044:c2043486-2043277 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT272711 WP_000138932.1 NZ_CP118044:c2043791-2043498 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References