Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2022016..2022545 Replicon chromosome
Accession NZ_CP118044
Organism Staphylococcus aureus strain VSI56

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PUW46_RS09885 Protein ID WP_000621175.1
Coordinates 2022016..2022378 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PUW46_RS09890 Protein ID WP_000948331.1
Coordinates 2022375..2022545 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW46_RS09865 (PUW46_09865) 2018980..2019750 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
PUW46_RS09870 (PUW46_09870) 2019725..2020204 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PUW46_RS09875 (PUW46_09875) 2020206..2020532 - 327 WP_001052491.1 anti-sigma factor antagonist -
PUW46_RS09880 (PUW46_09880) 2020651..2021667 - 1017 WP_275009411.1 PP2C family protein-serine/threonine phosphatase -
PUW46_RS09885 (PUW46_09885) 2022016..2022378 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PUW46_RS09890 (PUW46_09890) 2022375..2022545 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PUW46_RS09895 (PUW46_09895) 2022630..2023778 - 1149 WP_001281142.1 alanine racemase -
PUW46_RS09900 (PUW46_09900) 2023844..2024203 - 360 WP_000581197.1 holo-ACP synthase -
PUW46_RS09905 (PUW46_09905) 2024207..2024698 - 492 WP_001205910.1 PH domain-containing protein -
PUW46_RS09910 (PUW46_09910) 2024685..2026268 - 1584 WP_001294626.1 PH domain-containing protein -
PUW46_RS09915 (PUW46_09915) 2026261..2026740 - 480 WP_001287090.1 hypothetical protein -
PUW46_RS09920 (PUW46_09920) 2026949..2027509 - 561 WP_001092402.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T272710 WP_000621175.1 NZ_CP118044:c2022378-2022016 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT272710 WP_000948331.1 NZ_CP118044:c2022545-2022375 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References