272709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1868562..1869338 Replicon chromosome
Accession NZ_CP118044
Organism Staphylococcus aureus strain VSI56

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PUW46_RS08990 Protein ID WP_000031108.1
Coordinates 1868562..1868714 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag PUW46_RS08995 Protein ID WP_001251229.1
Coordinates 1868739..1869338 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW46_RS08975 (PUW46_08975) 1864478..1865299 + 822 WP_000669376.1 RluA family pseudouridine synthase -
PUW46_RS08980 (PUW46_08980) 1865752..1867137 - 1386 WP_000116231.1 class II fumarate hydratase -
PUW46_RS08985 (PUW46_08985) 1867333..1867728 - 396 WP_000901023.1 hypothetical protein -
PUW46_RS08990 (PUW46_08990) 1868562..1868714 - 153 WP_000031108.1 SAS053 family protein Toxin
PUW46_RS08995 (PUW46_08995) 1868739..1869338 - 600 WP_001251229.1 glucosamine-6-phosphate isomerase Antitoxin
PUW46_RS09000 (PUW46_09000) 1869496..1869966 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PUW46_RS09005 (PUW46_09005) 1869971..1871098 - 1128 WP_000379985.1 tRNA epoxyqueuosine(34) reductase QueG -
PUW46_RS09010 (PUW46_09010) 1871249..1871971 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PUW46_RS09015 (PUW46_09015) 1871964..1873421 - 1458 WP_000649913.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T272709 WP_000031108.1 NZ_CP118044:c1868714-1868562 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22329.45 Da        Isoelectric Point: 5.1445

>AT272709 WP_001251229.1 NZ_CP118044:c1869338-1868739 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEGLGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References