Detailed information of TA system TA272705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 685548..686812
• Replicon: chromosome
• Accession: NZ_CP118043
• Organism: Streptococcus agalactiae strain VSI63

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: PUW57_RS03885
• Protein ID: WP_032458611.1
• Coordinates: 686024..686812 (+)
• Length: 263 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: PUW57_RS03880
• Protein ID: WP_274999160.1
• Coordinates: 685548..686024 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PUW57_RS03835 (PUW57_03835)	680682..681003	+	322	Protein_672	DUF4368 domain-containing protein	-
PUW57_RS03840 (PUW57_03840)	680996..681955	+	960	Protein_673	hypothetical protein	-
PUW57_RS03845 (PUW57_03845)	682026..682325	+	300	WP_024408864.1	DUF5962 family protein	-
PUW57_RS03850 (PUW57_03850)	682339..682629	+	291	WP_024408865.1	DUF5966 family protein	-
PUW57_RS03855 (PUW57_03855)	682725..683355	+	631	Protein_676	peptidylprolyl isomerase	-
PUW57_RS03860 (PUW57_03860)	683395..684471	+	1077	WP_027971256.1	toprim domain-containing protein	-
PUW57_RS03865 (PUW57_03865)	684525..684752	+	228	WP_023370180.1	DUF5965 family protein	-
PUW57_RS03870 (PUW57_03870)	684749..685138	+	390	WP_032458613.1	DUF5945 family protein	-
PUW57_RS03875 (PUW57_03875)	685188..685478	+	291	WP_032458612.1	hypothetical protein	-
PUW57_RS03880 (PUW57_03880)	685548..686024	+	477	WP_274999160.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
PUW57_RS03885 (PUW57_03885)	686024..686812	+	789	WP_032458611.1	type II toxin-antitoxin system toxin PezT	Toxin
PUW57_RS03890 (PUW57_03890)	686802..688556	+	1755	WP_032458610.1	AAA family ATPase	-
PUW57_RS03895 (PUW57_03895)	688549..690090	+	1542	WP_024383488.1	UvrD-helicase domain-containing protein	-
PUW57_RS03900 (PUW57_03900)	690087..690497	+	411	WP_001873139.1	hypothetical protein	-
PUW57_RS03905 (PUW57_03905)	690503..690679	+	177	WP_001873137.1	hypothetical protein	-
PUW57_RS03910 (PUW57_03910)	691016..691378	+	363	WP_000140674.1	SAG1252 family conjugative relaxosome accessory protein	-
PUW57_RS03915 (PUW57_03915)	691381..691746	+	366	WP_000431640.1	MobC family plasmid mobilization relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / erm(B)	cylX / cylD / cylG / acpC / cylZ / cylA / cylB / cylE / cylF / cylI / cylJ / cylK	589539..756764	167225

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 263 a.a.
• Molecular weight: 29720.70 Da
• Isoelectric Point: 5.7391

>T272705 WP_032458611.1 NZ_CP118043:686024-686812 [Streptococcus agalactiae]
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKCSKVEEEMM
KLGRERLVKLNNKNLLESNYGI

Nucleotide

• Length: 789 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18301.73 Da
• Isoelectric Point: 4.3971

>AT272705 WP_274999160.1 NZ_CP118043:685548-686024 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp