272703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 652382..653814 Replicon chromosome
Accession NZ_CP118043
Organism Streptococcus agalactiae strain VSI63

Toxin (Protein)


Gene name abiEi Uniprot ID G7SFZ4
Locus tag PUW57_RS03700 Protein ID WP_001030299.1
Coordinates 652382..653227 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID G7SFZ3
Locus tag PUW57_RS03705 Protein ID WP_000037237.1
Coordinates 653224..653814 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW57_RS03695 (PUW57_03695) 649517..652318 + 2802 WP_043039313.1 phage tail tip lysozyme -
PUW57_RS03700 (PUW57_03700) 652382..653227 - 846 WP_001030299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PUW57_RS03705 (PUW57_03705) 653224..653814 - 591 WP_000037237.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / erm(B) cylX / cylD / cylG / acpC / cylZ / cylA / cylB / cylE / cylF / cylI / cylJ / cylK 589539..756764 167225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32462.14 Da        Isoelectric Point: 5.4404

>T272703 WP_001030299.1 NZ_CP118043:c653227-652382 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23056.59 Da        Isoelectric Point: 7.8056

>AT272703 WP_000037237.1 NZ_CP118043:c653814-653224 [Streptococcus agalactiae]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPLGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SFZ4

Antitoxin

Source ID Structure
AlphaFold DB G7SFZ3

References