Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2502853..2503418 Replicon chromosome
Accession NZ_CP118035
Organism Lacticaseibacillus rhamnosus strain VSI33

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag PUW67_RS11595 Protein ID WP_005692155.1
Coordinates 2502853..2503200 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PUW67_RS11600 Protein ID WP_020752297.1
Coordinates 2503200..2503418 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW67_RS11575 (PUW67_11575) 2498348..2499589 - 1242 WP_005692160.1 acyltransferase -
PUW67_RS11580 (PUW67_11580) 2499586..2500287 - 702 WP_005692159.1 ATP-binding cassette domain-containing protein -
PUW67_RS11585 (PUW67_11585) 2500280..2501098 - 819 WP_014571588.1 ABC transporter permease subunit -
PUW67_RS11590 (PUW67_11590) 2501339..2502007 - 669 WP_005692157.1 phenylalanine--tRNA ligase beta subunit-related protein -
PUW67_RS11595 (PUW67_11595) 2502853..2503200 - 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PUW67_RS11600 (PUW67_11600) 2503200..2503418 - 219 WP_020752297.1 hypothetical protein Antitoxin
PUW67_RS11605 (PUW67_11605) 2503512..2505347 - 1836 WP_015764721.1 ABC transporter ATP-binding protein -
PUW67_RS11610 (PUW67_11610) 2505334..2507124 - 1791 WP_015764722.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T272699 WP_005692155.1 NZ_CP118035:c2503200-2502853 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8117.33 Da        Isoelectric Point: 5.7995

>AT272699 WP_020752297.1 NZ_CP118035:c2503418-2503200 [Lacticaseibacillus rhamnosus]
MMDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75

Antitoxin

Source ID Structure

References