Detailed information of TA system TA272695

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1384653..1386076
• Replicon: chromosome
• Accession: NZ_CP118029
• Organism: Streptococcus anginosus strain VSI68

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: PUW70_RS06960
• Protein ID: WP_150902377.1
• Coordinates: 1385240..1386076 (+)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: PUW70_RS06955
• Protein ID: WP_101750350.1
• Coordinates: 1384653..1385243 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PUW70_RS06940 (PUW70_06940)	1381283..1383196	+	1914	WP_101750353.1	conjugal transfer protein	-
PUW70_RS06945 (PUW70_06945)	1383183..1383410	+	228	WP_101750352.1	hypothetical protein	-
PUW70_RS06950 (PUW70_06950)	1383429..1384541	+	1113	WP_274995809.1	phage tail tip lysozyme	-
PUW70_RS06955 (PUW70_06955)	1384653..1385243	+	591	WP_101750350.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PUW70_RS06960 (PUW70_06960)	1385240..1386076	+	837	WP_150902377.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PUW70_RS06965 (PUW70_06965)	1386261..1386458	+	198	WP_006738512.1	excisionase	-
PUW70_RS06970 (PUW70_06970)	1386523..1387773	+	1251	WP_101750348.1	site-specific integrase	-
PUW70_RS06975 (PUW70_06975)	1388306..1388848	-	543	WP_150861523.1	DUF6036 family nucleotidyltransferase	-
PUW70_RS06980 (PUW70_06980)	1388841..1389128	-	288	WP_024053040.1	hypothetical protein	-
PUW70_RS06985 (PUW70_06985)	1389131..1389586	-	456	WP_024053039.1	hypothetical protein	-
PUW70_RS06990 (PUW70_06990)	1389576..1390493	-	918	WP_150861524.1	IS1595 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1353947..1397437	43490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31923.31 Da
• Isoelectric Point: 5.1824

>T272695 WP_150902377.1 NZ_CP118029:1385240-1386076 [Streptococcus anginosus]
VNKAKLTALCHKVSKETGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDVYILSKLKKSEIDSQQLLTACQRTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23137.46 Da
• Isoelectric Point: 8.3205

>AT272695 WP_101750350.1 NZ_CP118029:1384653-1385243 [Streptococcus anginosus]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGFTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVPKEIVDLGVISVKTPWGQTVKTYDFERIICDFIQNRKKIDNELFAKT
LKAYVNYPNKNLTNLYQYAEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp