Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 33304..33863 Replicon plasmid unnamed1
Accession NZ_CP118015
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name relE Uniprot ID E0J3F0
Locus tag PT280_RS24970 Protein ID WP_000421267.1
Coordinates 33304..33579 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag PT280_RS24975 Protein ID WP_001178087.1
Coordinates 33579..33863 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS24940 28638..29324 - 687 Protein_31 colicin-Ia domain protein -
PT280_RS24945 29602..30948 - 1347 WP_001132027.1 protein YagA -
PT280_RS24950 31302..31904 + 603 WP_000517697.1 ProQ/FINO family protein -
PT280_RS24955 31960..32454 + 495 WP_001350009.1 hypothetical protein -
PT280_RS24960 32454..32720 + 267 WP_000627834.1 hypothetical protein -
PT280_RS24965 32989..33198 - 210 Protein_36 hypothetical protein -
PT280_RS24970 33304..33579 - 276 WP_000421267.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT280_RS24975 33579..33863 - 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
PT280_RS24980 34767..35798 - 1032 WP_000907868.1 plasmid replication initiator RepA -
PT280_RS24985 36755..36910 + 156 Protein_40 ash family protein -
PT280_RS24990 36951..37238 + 288 WP_000074853.1 hypothetical protein -
PT280_RS24995 37680..38213 + 534 WP_001350011.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeG / faeF / faeE / faeD / faeC 1..122614 122614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10788.48 Da        Isoelectric Point: 9.9325

>T272692 WP_000421267.1 NZ_CP118015:c33579-33304 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLTSKPAAARTVQSLTHAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT272692 WP_001178087.1 NZ_CP118015:c33863-33579 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References