Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4997904..4998499 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PT280_RS24415 Protein ID WP_000239579.1
Coordinates 4997904..4998254 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PT280_RS24420 Protein ID WP_001223208.1
Coordinates 4998248..4998499 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS24395 (4993350) 4993350..4994372 - 1023 WP_001296689.1 ABC transporter permease -
PT280_RS24400 (4994386) 4994386..4995888 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
PT280_RS24405 (4996028) 4996028..4996984 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PT280_RS24410 (4997294) 4997294..4997824 + 531 WP_000055072.1 inorganic diphosphatase -
PT280_RS24415 (4997904) 4997904..4998254 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PT280_RS24420 (4998248) 4998248..4998499 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PT280_RS24425 (4998712) 4998712..4999053 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PT280_RS24430 (4999056) 4999056..5002835 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T272691 WP_000239579.1 NZ_CP118014:c4998254-4997904 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT272691 WP_001223208.1 NZ_CP118014:c4998499-4998248 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References