272690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4930502..4931209 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name ykfI Uniprot ID E0J2C8
Locus tag PT280_RS24095 Protein ID WP_000691790.1
Coordinates 4930502..4930843 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PT280_RS24100 Protein ID WP_000939438.1
Coordinates 4930874..4931209 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS24075 (4926491) 4926491..4927756 - 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
PT280_RS24080 (4928149) 4928149..4929096 - 948 WP_000342500.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
PT280_RS24085 (4929089) 4929089..4929484 - 396 WP_000152741.1 DUF6088 family protein -
PT280_RS24090 (4929554) 4929554..4930387 - 834 WP_001192746.1 DUF4942 domain-containing protein -
PT280_RS24095 (4930502) 4930502..4930843 - 342 WP_000691790.1 TA system toxin CbtA family protein Toxin
PT280_RS24100 (4930874) 4930874..4931209 - 336 WP_000939438.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PT280_RS24105 (4931209) 4931209..4931682 - 474 WP_001292742.1 DNA repair protein RadC -
PT280_RS24110 (4931712) 4931712..4932530 - 819 WP_000761991.1 DUF932 domain-containing protein -
PT280_RS24115 (4932766) 4932766..4933719 - 954 WP_000290405.1 hypothetical protein -
PT280_RS24120 (4934312) 4934312..4934926 + 615 WP_000772909.1 inovirus Gp2 family protein -
PT280_RS24125 (4935044) 4935044..4935262 + 219 WP_001064742.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4897808..4947060 49252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13060.08 Da        Isoelectric Point: 9.4583

>T272690 WP_000691790.1 NZ_CP118014:c4930843-4930502 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCYNTTAR

Download         Length: 342 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12639.63 Da        Isoelectric Point: 7.7723

>AT272690 WP_000939438.1 NZ_CP118014:c4931209-4930874 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPWQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J2C8

Antitoxin

Source ID Structure

References