272689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4928149..4929484 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name sanaT Uniprot ID E0J2C5
Locus tag PT280_RS24080 Protein ID WP_000342500.1
Coordinates 4928149..4929096 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID E0J2C6
Locus tag PT280_RS24085 Protein ID WP_000152741.1
Coordinates 4929089..4929484 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS24065 (4924282) 4924282..4924824 + 543 WP_001115385.1 hypothetical protein -
PT280_RS24070 (4924821) 4924821..4926290 + 1470 WP_001022619.1 serine/threonine-protein kinase -
PT280_RS24075 (4926491) 4926491..4927756 - 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
PT280_RS24080 (4928149) 4928149..4929096 - 948 WP_000342500.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PT280_RS24085 (4929089) 4929089..4929484 - 396 WP_000152741.1 DUF6088 family protein Antitoxin
PT280_RS24090 (4929554) 4929554..4930387 - 834 WP_001192746.1 DUF4942 domain-containing protein -
PT280_RS24095 (4930502) 4930502..4930843 - 342 WP_000691790.1 TA system toxin CbtA family protein -
PT280_RS24100 (4930874) 4930874..4931209 - 336 WP_000939438.1 type IV toxin-antitoxin system YeeU family antitoxin -
PT280_RS24105 (4931209) 4931209..4931682 - 474 WP_001292742.1 DNA repair protein RadC -
PT280_RS24110 (4931712) 4931712..4932530 - 819 WP_000761991.1 DUF932 domain-containing protein -
PT280_RS24115 (4932766) 4932766..4933719 - 954 WP_000290405.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4897808..4947060 49252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35562.71 Da        Isoelectric Point: 4.9737

>T272689 WP_000342500.1 NZ_CP118014:c4929096-4928149 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGSTGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14619.93 Da        Isoelectric Point: 11.6915

>AT272689 WP_000152741.1 NZ_CP118014:c4929484-4929089 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J2C5

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4ZXD4

References