272687

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 4279451..4280288 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag PT280_RS20980 Protein ID WP_000227784.1
Coordinates 4279746..4280288 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag PT280_RS20975 Protein ID WP_001297137.1
Coordinates 4279451..4279762 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS20950 (4274471) 4274471..4275418 + 948 WP_001239440.1 cytochrome o ubiquinol oxidase subunit II -
PT280_RS20955 (4275440) 4275440..4277431 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
PT280_RS20960 (4277421) 4277421..4278035 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PT280_RS20965 (4278035) 4278035..4278364 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PT280_RS20970 (4278376) 4278376..4279266 + 891 WP_000971336.1 heme o synthase -
PT280_RS20975 (4279451) 4279451..4279762 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
PT280_RS20980 (4279746) 4279746..4280288 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
PT280_RS20985 (4280344) 4280344..4281268 - 925 Protein_4067 tetratricopeptide repeat protein -
PT280_RS20990 (4281676) 4281676..4283040 + 1365 WP_001000978.1 MFS transporter -
PT280_RS20995 (4283168) 4283168..4283659 - 492 WP_001138904.1 nucleotide binding protein YajQ -
PT280_RS21000 (4283827) 4283827..4284738 + 912 WP_000705849.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T272687 WP_000227784.1 NZ_CP118014:4279746-4280288 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT272687 WP_001297137.1 NZ_CP118014:4279451-4279762 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References