Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4245374..4245992 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PT280_RS20810 Protein ID WP_001291435.1
Coordinates 4245774..4245992 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PT280_RS20805 Protein ID WP_000344800.1
Coordinates 4245374..4245748 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS20795 (4240445) 4240445..4241638 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PT280_RS20800 (4241661) 4241661..4244828 + 3168 WP_274292398.1 efflux RND transporter permease AcrB -
PT280_RS20805 (4245374) 4245374..4245748 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PT280_RS20810 (4245774) 4245774..4245992 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PT280_RS20815 (4246164) 4246164..4246715 + 552 WP_000102564.1 maltose O-acetyltransferase -
PT280_RS20820 (4246831) 4246831..4247301 + 471 WP_000136192.1 YlaC family protein -
PT280_RS20825 (4247465) 4247465..4249015 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PT280_RS20830 (4249057) 4249057..4249410 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PT280_RS20840 (4249789) 4249789..4250100 + 312 WP_000409911.1 MGMT family protein -
PT280_RS20845 (4250131) 4250131..4250703 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T272686 WP_001291435.1 NZ_CP118014:4245774-4245992 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT272686 WP_000344800.1 NZ_CP118014:4245374-4245748 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References