Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3136745..3137383 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PT280_RS15400 Protein ID WP_000813794.1
Coordinates 3137207..3137383 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PT280_RS15395 Protein ID WP_001270285.1
Coordinates 3136745..3137161 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS15375 (3131897) 3131897..3132838 - 942 WP_001251315.1 ABC transporter permease -
PT280_RS15380 (3132839) 3132839..3133852 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PT280_RS15385 (3133870) 3133870..3135015 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
PT280_RS15390 (3135260) 3135260..3136666 - 1407 WP_000760589.1 PLP-dependent aminotransferase family protein -
PT280_RS15395 (3136745) 3136745..3137161 - 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PT280_RS15400 (3137207) 3137207..3137383 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PT280_RS15405 (3137605) 3137605..3137835 + 231 WP_000494244.1 YncJ family protein -
PT280_RS15410 (3137927) 3137927..3139888 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PT280_RS15415 (3139961) 3139961..3140497 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PT280_RS15420 (3140550) 3140550..3141764 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3141804..3142952 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T272685 WP_000813794.1 NZ_CP118014:c3137383-3137207 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT272685 WP_001270285.1 NZ_CP118014:c3137161-3136745 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References