272683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2962300..2962826 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PT280_RS14560 Protein ID WP_000323025.1
Coordinates 2962539..2962826 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PT280_RS14555 Protein ID WP_000534858.1
Coordinates 2962300..2962539 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS14525 (2957662) 2957662..2958151 + 490 Protein_2804 class I SAM-dependent methyltransferase -
PT280_RS14530 (2958629) 2958629..2959050 + 422 Protein_2805 hypothetical protein -
PT280_RS14535 (2959706) 2959706..2960776 + 1071 Protein_2806 ISNCY family transposase -
PT280_RS14540 (2960849) 2960849..2960998 + 150 WP_011443592.1 protein YdfW -
PT280_RS14545 (2961435) 2961435..2961767 - 333 WP_001301033.1 FlxA-like family protein -
PT280_RS14550 (2961970) 2961970..2962275 - 306 WP_001326990.1 protein YdfV -
PT280_RS14555 (2962300) 2962300..2962539 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PT280_RS14560 (2962539) 2962539..2962826 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PT280_RS14565 (2962898) 2962898..2963053 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
PT280_RS14570 (2963270) 2963270..2963521 + 252 WP_000980994.1 protein Rem -
PT280_RS14575 (2963588) 2963588..2963866 + 279 WP_012304870.1 hypothetical protein -
PT280_RS14580 (2963868) 2963868..2964917 + 1050 WP_001265199.1 DUF968 domain-containing protein -
PT280_RS14585 (2964931) 2964931..2965683 + 753 WP_001047135.1 antitermination protein -
PT280_RS14590 (2965961) 2965961..2966050 - 90 WP_120795389.1 hypothetical protein -
PT280_RS14595 (2966105) 2966105..2966317 - 213 WP_000087756.1 cold shock-like protein CspF -
PT280_RS14600 (2966618) 2966618..2966833 + 216 WP_000066484.1 cold shock-like protein CspB -
PT280_RS14605 (2967197) 2967197..2967367 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
PT280_RS14610 (2967587) 2967587..2967802 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2937422..3000014 62592
- inside Prophage - - 2944015..3000878 56863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T272683 WP_000323025.1 NZ_CP118014:2962539-2962826 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT272683 WP_000534858.1 NZ_CP118014:2962300-2962539 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References