272677

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1953967..1954592 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PT280_RS09505 Protein ID WP_000911329.1
Coordinates 1954194..1954592 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PT280_RS09500 Protein ID WP_000450524.1
Coordinates 1953967..1954194 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS09475 (1949769) 1949769..1950239 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PT280_RS09480 (1950239) 1950239..1950811 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PT280_RS09485 (1950957) 1950957..1951835 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PT280_RS09490 (1951852) 1951852..1952886 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PT280_RS09495 (1953099) 1953099..1953812 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PT280_RS09500 (1953967) 1953967..1954194 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PT280_RS09505 (1954194) 1954194..1954592 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PT280_RS09510 (1954739) 1954739..1955602 + 864 WP_001267498.1 neutral zinc metallopeptidase -
PT280_RS09515 (1955617) 1955617..1957632 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
PT280_RS09520 (1957706) 1957706..1958404 + 699 WP_000679823.1 esterase -
PT280_RS09525 (1958485) 1958485..1958685 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T272677 WP_000911329.1 NZ_CP118014:1954194-1954592 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT272677 WP_000450524.1 NZ_CP118014:1953967-1954194 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References