272672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 876262..876848 Replicon chromosome
Accession NZ_CP118014
Organism Escherichia coli strain B-766

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PT280_RS04185 Protein ID WP_042014162.1
Coordinates 876262..876492 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PT280_RS04190 Protein ID WP_000593555.1
Coordinates 876489..876848 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT280_RS04175 (872299) 872299..875034 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
PT280_RS04180 (875034) 875034..876158 + 1125 WP_001314210.1 ABC transporter permease -
PT280_RS04185 (876262) 876262..876492 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PT280_RS04190 (876489) 876489..876848 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PT280_RS04195 (876968) 876968..877369 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PT280_RS04200 (877375) 877375..878181 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PT280_RS04205 (878178) 878178..878942 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PT280_RS04210 (878942) 878942..879775 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PT280_RS04215 (879772) 879772..880716 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T272672 WP_042014162.1 NZ_CP118014:876262-876492 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT272672 WP_000593555.1 NZ_CP118014:876489-876848 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References