Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2339042..2339873 Replicon chromosome
Accession NC_017631
Organism Escherichia coli ABU 83972

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag ECABU_RS11845 Protein ID WP_000854814.1
Coordinates 2339499..2339873 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag ECABU_RS11840 Protein ID WP_001285586.1
Coordinates 2339042..2339410 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECABU_RS11805 2334099..2335169 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
ECABU_RS11810 2335305..2335982 + 678 WP_001362823.1 hypothetical protein -
ECABU_RS11815 2335998..2336408 + 411 WP_000846704.1 hypothetical protein -
ECABU_RS11820 2336629..2337450 + 822 WP_001234571.1 DUF945 domain-containing protein -
ECABU_RS11825 2337713..2338186 + 474 WP_000855074.1 antirestriction protein -
ECABU_RS11830 2338202..2338678 + 477 WP_001351157.1 RadC family protein -
ECABU_RS11835 2338747..2338968 + 222 WP_000692323.1 DUF987 domain-containing protein -
ECABU_RS11840 2339042..2339410 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
ECABU_RS11845 2339499..2339873 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
ECABU_RS11850 2339870..2340064 + 195 WP_000988601.1 hypothetical protein -
ECABU_RS28630 2340077..2340190 + 114 WP_001161660.1 DUF957 domain-containing protein -
ECABU_RS26635 2340479..2340625 - 147 Protein_2245 transposase domain-containing protein -
ECABU_RS11860 2340679..2340861 + 183 WP_001016348.1 hypothetical protein -
ECABU_RS11865 2340962..2341291 - 330 WP_000450409.1 DUF496 family protein -
ECABU_RS11870 2341463..2342521 - 1059 WP_001200890.1 FUSC family protein -
ECABU_RS11875 2342719..2343192 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
ECABU_RS11880 2343311..2344477 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T27267 WP_000854814.1 NC_017631:2339499-2339873 [Escherichia coli ABU 83972]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27267 NC_017631:2339499-2339873 [Escherichia coli ABU 83972]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT27267 WP_001285586.1 NC_017631:2339042-2339410 [Escherichia coli ABU 83972]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT27267 NC_017631:2339042-2339410 [Escherichia coli ABU 83972]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References