Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4580208..4580824 Replicon chromosome
Accession NZ_CP117993
Organism Enterobacter hormaechei isolate 1023017620-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PUO93_RS22660 Protein ID WP_015569913.1
Coordinates 4580453..4580824 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag PUO93_RS22655 Protein ID WP_015569912.1
Coordinates 4580208..4580450 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO93_RS22625 4575267..4576067 + 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -
PUO93_RS22630 4576186..4576785 + 600 WP_048246664.1 glucose-1-phosphatase -
PUO93_RS22635 4576779..4577660 + 882 WP_003861949.1 virulence factor BrkB family protein -
PUO93_RS22640 4577657..4578094 + 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
PUO93_RS22645 4578139..4579080 + 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
PUO93_RS22650 4579089..4580009 - 921 WP_015569911.1 alpha/beta hydrolase -
PUO93_RS22655 4580208..4580450 + 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
PUO93_RS22660 4580453..4580824 + 372 WP_015569913.1 PIN domain-containing protein Toxin
PUO93_RS22665 4580864..4581793 - 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
PUO93_RS22670 4581790..4582425 - 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
PUO93_RS22675 4582422..4583324 - 903 WP_014072386.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T272664 WP_015569913.1 NZ_CP117993:4580453-4580824 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT272664 WP_015569912.1 NZ_CP117993:4580208-4580450 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References