272663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4386116..4386783 Replicon chromosome
Accession NZ_CP117993
Organism Enterobacter hormaechei isolate 1023017620-1

Toxin (Protein)


Gene name ypjF Uniprot ID E1IS66
Locus tag PUO93_RS21725 Protein ID WP_000856973.1
Coordinates 4386463..4386783 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID E1IS67
Locus tag PUO93_RS21720 Protein ID WP_000052843.1
Coordinates 4386116..4386442 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO93_RS21695 4381804..4382697 + 894 WP_000033877.1 50S ribosome-binding GTPase -
PUO93_RS21700 4382889..4383578 + 690 WP_274292324.1 WYL domain-containing protein -
PUO93_RS21705 4383640..4384650 + 1011 WP_001348677.1 hypothetical protein -
PUO93_RS21710 4384743..4385564 + 822 WP_213193600.1 DUF932 domain-containing protein -
PUO93_RS21715 4385633..4386103 + 471 WP_001275770.1 DNA repair protein RadC -
PUO93_RS21720 4386116..4386442 + 327 WP_000052843.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PUO93_RS21725 4386463..4386783 + 321 WP_000856973.1 TA system toxin CbtA family protein Toxin
PUO93_RS21730 4386918..4388753 - 1836 WP_126850588.1 P-loop NTPase fold protein -
PUO93_RS21735 4388768..4388956 - 189 WP_075550043.1 toxin-antitoxin system HicB family antitoxin -
PUO93_RS21740 4389093..4389434 + 342 WP_015570064.1 SymE family type I addiction module toxin -
PUO93_RS21745 4389485..4390522 + 1038 WP_048246604.1 RhuM family protein -
PUO93_RS21750 4390786..4391271 + 486 WP_045338680.1 type VI secretion system tube protein TssD -
PUO93_RS21755 4391281..4391646 + 366 WP_023302859.1 DUF2778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp/tssD 4375325..4407733 32408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12080.87 Da        Isoelectric Point: 5.5873

>T272663 WP_000856973.1 NZ_CP117993:4386463-4386783 [Enterobacter hormaechei]
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12305.01 Da        Isoelectric Point: 6.3620

>AT272663 WP_000052843.1 NZ_CP117993:4386116-4386442 [Enterobacter hormaechei]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345ENE3

Antitoxin

Source ID Structure
AlphaFold DB A0A345ENE4

References