Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3851000..3851576 Replicon chromosome
Accession NZ_CP117993
Organism Enterobacter hormaechei isolate 1023017620-1

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag PUO93_RS19130 Protein ID WP_015572580.1
Coordinates 3851289..3851576 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag PUO93_RS19125 Protein ID WP_017694570.1
Coordinates 3851000..3851302 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO93_RS19105 3847291..3847836 + 546 WP_006810254.1 YfaZ family outer membrane protein -
PUO93_RS19110 3848018..3849388 - 1371 WP_017694568.1 NAD-dependent succinate-semialdehyde dehydrogenase -
PUO93_RS19115 3849542..3850294 + 753 WP_015572582.1 AraC family transcriptional regulator -
PUO93_RS19120 3850333..3850971 + 639 WP_017694569.1 LysE family translocator -
PUO93_RS19125 3851000..3851302 - 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
PUO93_RS19130 3851289..3851576 - 288 WP_015572580.1 BrnT family toxin Toxin
PUO93_RS19135 3851751..3853022 + 1272 WP_017694571.1 DUF445 domain-containing protein -
PUO93_RS19140 3853019..3854095 - 1077 WP_015572578.1 DUF2955 domain-containing protein -
PUO93_RS19145 3854085..3855152 - 1068 WP_026094404.1 HlyD family secretion protein -
PUO93_RS19150 3855149..3855619 - 471 WP_015572576.1 MarR family transcriptional regulator -
PUO93_RS19155 3855769..3856488 - 720 WP_017694573.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T272662 WP_015572580.1 NZ_CP117993:c3851576-3851289 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT272662 WP_017694570.1 NZ_CP117993:c3851302-3851000 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References