Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3366474..3367094 Replicon chromosome
Accession NZ_CP117993
Organism Enterobacter hormaechei isolate 1023017620-1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag PUO93_RS16865 Protein ID WP_015571250.1
Coordinates 3366876..3367094 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag PUO93_RS16860 Protein ID WP_006809850.1
Coordinates 3366474..3366848 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO93_RS16850 3361601..3362794 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PUO93_RS16855 3362817..3365963 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
PUO93_RS16860 3366474..3366848 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
PUO93_RS16865 3366876..3367094 + 219 WP_015571250.1 HHA domain-containing protein Toxin
PUO93_RS16870 3367303..3367854 + 552 WP_015571251.1 maltose O-acetyltransferase -
PUO93_RS16875 3367971..3368438 + 468 WP_048247738.1 YlaC family protein -
PUO93_RS16880 3368410..3369870 - 1461 WP_048247740.1 PLP-dependent aminotransferase family protein -
PUO93_RS16885 3369972..3370682 + 711 WP_048247742.1 GNAT family protein -
PUO93_RS16890 3370679..3370819 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PUO93_RS16895 3370822..3371082 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T272661 WP_015571250.1 NZ_CP117993:3366876-3367094 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT272661 WP_006809850.1 NZ_CP117993:3366474-3366848 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References