Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2739482..2740279 Replicon chromosome
Accession NZ_CP117993
Organism Enterobacter hormaechei isolate 1023017620-1

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag PUO93_RS13790 Protein ID WP_040117472.1
Coordinates 2739482..2740003 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5RT92
Locus tag PUO93_RS13795 Protein ID WP_001303459.1
Coordinates 2740010..2740279 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO93_RS13760 2735080..2735769 + 690 WP_040117478.1 pyrimidine utilization protein B -
PUO93_RS13765 2735781..2736167 + 387 WP_040117477.1 pyrimidine utilization protein C -
PUO93_RS13770 2736175..2736975 + 801 WP_047735077.1 pyrimidine utilization protein D -
PUO93_RS13775 2736985..2737575 + 591 WP_040117475.1 malonic semialdehyde reductase -
PUO93_RS13780 2737588..2738079 + 492 WP_040117474.1 pyrimidine utilization flavin reductase protein F -
PUO93_RS13785 2738101..2739423 + 1323 WP_040117473.1 pyrimidine utilization transport protein G -
PUO93_RS13790 2739482..2740003 - 522 WP_040117472.1 GNAT family N-acetyltransferase Toxin
PUO93_RS13795 2740010..2740279 - 270 WP_001303459.1 DUF1778 domain-containing protein Antitoxin
PUO93_RS13800 2740353..2741258 - 906 WP_017693666.1 DMT family transporter -
PUO93_RS13805 2741375..2741545 - 171 WP_001273664.1 general stress protein -
PUO93_RS13810 2741937..2742533 + 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
PUO93_RS13815 2742552..2742779 + 228 WP_006809324.1 YccJ family protein -
PUO93_RS13820 2742812..2744053 - 1242 WP_017693667.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
PUO93_RS13825 2744206..2744301 + 96 Protein_2556 transcriptional regulator -
PUO93_RS13830 2744380..2744739 - 360 WP_017384779.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19437.18 Da        Isoelectric Point: 7.4317

>T272660 WP_040117472.1 NZ_CP117993:c2740003-2739482 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTDHLVRQHGGRILRGYLLKERDHPRILGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10248.70 Da        Isoelectric Point: 5.8836

>AT272660 WP_001303459.1 NZ_CP117993:c2740279-2740010 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7BCZ2

References