Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2172423..2173162 Replicon chromosome
Accession NZ_CP117993
Organism Enterobacter hormaechei isolate 1023017620-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag PUO93_RS11040 Protein ID WP_003857133.1
Coordinates 2172677..2173162 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag PUO93_RS11035 Protein ID WP_003857131.1
Coordinates 2172423..2172689 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO93_RS11015 2167915..2168901 + 987 WP_047637343.1 DUF979 domain-containing protein -
PUO93_RS11020 2168911..2169906 + 996 WP_048247348.1 DUF2891 domain-containing protein -
PUO93_RS11025 2169929..2171311 - 1383 WP_045911739.1 MFS transporter -
PUO93_RS11030 2171441..2172359 + 919 Protein_2003 LysR family transcriptional regulator -
PUO93_RS11035 2172423..2172689 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
PUO93_RS11040 2172677..2173162 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
PUO93_RS11045 2173343..2173671 + 329 Protein_2006 ISNCY family transposase -
PUO93_RS11050 2174100..2174546 + 447 WP_014069654.1 DUF3290 domain-containing protein -
PUO93_RS11055 2174556..2175191 + 636 WP_015570517.1 DUF421 domain-containing protein -
PUO93_RS11060 2175375..2175989 - 615 WP_080337332.1 NUDIX hydrolase -
PUO93_RS11065 2175989..2177281 - 1293 WP_048247370.1 glycosyl hydrolase family 28 protein -
PUO93_RS11070 2177386..2178144 - 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T272659 WP_003857133.1 NZ_CP117993:2172677-2173162 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT272659 WP_003857131.1 NZ_CP117993:2172423-2172689 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References