Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2432523..2433052 Replicon chromosome
Accession NZ_CP117979
Organism Staphylococcus aureus strain B-41012

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PT798_RS11845 Protein ID WP_000621175.1
Coordinates 2432523..2432885 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PT798_RS11850 Protein ID WP_000948331.1
Coordinates 2432882..2433052 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT798_RS11825 2429501..2430271 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
PT798_RS11830 2430246..2430725 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PT798_RS11835 2430727..2431053 - 327 WP_001052491.1 anti-sigma factor antagonist -
PT798_RS11840 2431172..2432173 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PT798_RS11845 2432523..2432885 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PT798_RS11850 2432882..2433052 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PT798_RS11855 2433137..2434285 - 1149 WP_001281154.1 alanine racemase -
PT798_RS11860 2434351..2434710 - 360 WP_000581197.1 holo-ACP synthase -
PT798_RS11865 2434714..2435205 - 492 WP_072353916.1 PH domain-containing protein -
PT798_RS11870 2435192..2436775 - 1584 WP_001294626.1 PH domain-containing protein -
PT798_RS11875 2436768..2437247 - 480 WP_031590204.1 hypothetical protein -
PT798_RS11880 2437456..2438016 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T272641 WP_000621175.1 NZ_CP117979:c2432885-2432523 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT272641 WP_000948331.1 NZ_CP117979:c2433052-2432882 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References