Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2275329..2276105 Replicon chromosome
Accession NZ_CP117979
Organism Staphylococcus aureus strain B-41012

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PT798_RS10930 Protein ID WP_000031108.1
Coordinates 2275329..2275481 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag PT798_RS10935 Protein ID WP_001251230.1
Coordinates 2275506..2276105 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT798_RS10915 2271417..2272238 + 822 WP_000669376.1 RluA family pseudouridine synthase -
PT798_RS10920 2272690..2274075 - 1386 WP_000116229.1 class II fumarate hydratase -
PT798_RS10925 2274271..2274666 - 396 WP_000901023.1 hypothetical protein -
PT798_RS10930 2275329..2275481 - 153 WP_000031108.1 SAS053 family protein Toxin
PT798_RS10935 2275506..2276105 - 600 WP_001251230.1 hypothetical protein Antitoxin
PT798_RS10940 2276264..2276734 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PT798_RS10945 2276739..2277866 - 1128 WP_031590038.1 tRNA epoxyqueuosine(34) reductase QueG -
PT798_RS10950 2278017..2278739 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PT798_RS10955 2278732..2280189 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T272640 WP_000031108.1 NZ_CP117979:c2275481-2275329 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22369.51 Da        Isoelectric Point: 4.9728

>AT272640 WP_001251230.1 NZ_CP117979:c2276105-2275506 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKYAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References