Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4361687..4362347 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PT747_RS21240 Protein ID WP_000244756.1
Coordinates 4361687..4362100 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PT747_RS21245 Protein ID WP_000351186.1
Coordinates 4362081..4362347 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS21220 (4357628) 4357628..4359361 - 1734 WP_000813392.1 single-stranded-DNA-specific exonuclease RecJ -
PT747_RS21225 (4359367) 4359367..4360080 - 714 WP_001540860.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PT747_RS21230 (4360104) 4360104..4361000 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PT747_RS21235 (4361113) 4361113..4361634 + 522 WP_001055885.1 flavodoxin FldB -
PT747_RS21240 (4361687) 4361687..4362100 - 414 WP_000244756.1 protein YgfX Toxin
PT747_RS21245 (4362081) 4362081..4362347 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PT747_RS21250 (4362597) 4362597..4363577 + 981 WP_000874173.1 tRNA-modifying protein YgfZ -
PT747_RS21255 (4363693) 4363693..4364352 - 660 WP_023235227.1 hemolysin III family protein -
PT747_RS21260 (4364516) 4364516..4364827 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PT747_RS21265 (4364985) 4364985..4366418 + 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T272632 WP_000244756.1 NZ_CP117976:c4362100-4361687 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT272632 WP_000351186.1 NZ_CP117976:c4362347-4362081 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References