Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4350802..4351427 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PT747_RS21175 Protein ID WP_000911337.1
Coordinates 4350802..4351200 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag PT747_RS21180 Protein ID WP_000557545.1
Coordinates 4351200..4351427 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS21160 (4347478) 4347478..4348062 - 585 WP_001244638.1 fimbrial protein -
PT747_RS21165 (4348781) 4348781..4349413 - 633 WP_001540855.1 YfdX family protein -
PT747_RS21170 (4349460) 4349460..4349996 - 537 WP_001038500.1 STM3031 family outer membrane protein -
PT747_RS21175 (4350802) 4350802..4351200 - 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PT747_RS21180 (4351200) 4351200..4351427 - 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
PT747_RS21185 (4351636) 4351636..4351887 + 252 WP_001540858.1 hypothetical protein -
PT747_RS21190 (4352162) 4352162..4352969 + 808 Protein_4129 DUF1460 domain-containing protein -
PT747_RS21200 (4353254) 4353254..4354012 - 759 WP_000244328.1 amidase activator ActS -
PT747_RS21205 (4354277) 4354277..4354822 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PT747_RS21210 (4354898) 4354898..4356415 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4342405..4352969 10564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T272631 WP_000911337.1 NZ_CP117976:c4351200-4350802 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT272631 WP_000557545.1 NZ_CP117976:c4351427-4351200 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References