Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4196783..4197597 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag PT747_RS20470 Protein ID WP_000971655.1
Coordinates 4197070..4197597 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PT747_RS20465 Protein ID WP_000855694.1
Coordinates 4196783..4197073 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS20445 (4192676) 4192676..4194364 - 1689 WP_001540787.1 type III secretion system outer membrane ring protein InvG -
PT747_RS20450 (4194361) 4194361..4195011 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
PT747_RS20455 (4195467) 4195467..4195910 + 444 WP_000715102.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PT747_RS20460 (4196328) 4196328..4196513 + 186 Protein_3986 IS3 family transposase -
PT747_RS20465 (4196783) 4196783..4197073 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PT747_RS20470 (4197070) 4197070..4197597 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
PT747_RS20475 (4197670) 4197670..4197885 - 216 Protein_3989 IS5/IS1182 family transposase -
PT747_RS20480 (4198223) 4198223..4198879 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
PT747_RS20485 (4199124) 4199124..4199618 - 495 WP_001540790.1 hypothetical protein -
PT747_RS20490 (4199645) 4199645..4200313 - 669 WP_001540791.1 hypothetical protein -
PT747_RS20495 (4200470) 4200470..4200709 - 240 Protein_3993 hypothetical protein -
PT747_RS20500 (4200900) 4200900..4201298 - 399 Protein_3994 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4197670..4197810 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T272630 WP_000971655.1 NZ_CP117976:4197070-4197597 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT272630 WP_000855694.1 NZ_CP117976:4196783-4197073 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References