Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1770444..1771064 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PT747_RS08320 Protein ID WP_001280991.1
Coordinates 1770444..1770662 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PT747_RS08325 Protein ID WP_000344807.1
Coordinates 1770690..1771064 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS08280 (1765808) 1765808..1766377 + 570 WP_000779802.1 YbaY family lipoprotein -
PT747_RS08285 (1766410) 1766410..1766799 - 390 WP_000961285.1 MGMT family protein -
PT747_RS08295 (1767030) 1767030..1768439 - 1410 WP_038393950.1 EAL domain-containing protein -
PT747_RS08300 (1768664) 1768664..1768924 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PT747_RS08305 (1768930) 1768930..1769070 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PT747_RS08310 (1769126) 1769126..1769596 - 471 WP_000136183.1 YlaC family protein -
PT747_RS08315 (1769714) 1769714..1770265 - 552 WP_001278793.1 maltose O-acetyltransferase -
PT747_RS08320 (1770444) 1770444..1770662 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PT747_RS08325 (1770690) 1770690..1771064 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PT747_RS08330 (1771560) 1771560..1774709 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PT747_RS08335 (1774732) 1774732..1775925 - 1194 WP_023235518.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T272624 WP_001280991.1 NZ_CP117976:c1770662-1770444 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT272624 WP_000344807.1 NZ_CP117976:c1771064-1770690 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References