Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1010591..1011107 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PT747_RS04655 Protein ID WP_000220578.1
Coordinates 1010823..1011107 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PT747_RS04650 Protein ID WP_000212724.1
Coordinates 1010591..1010833 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS04630 (1005591) 1005591..1006724 + 1134 WP_000459940.1 amidohydrolase/deacetylase family metallohydrolase -
PT747_RS04635 (1006708) 1006708..1007826 + 1119 WP_001139177.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PT747_RS04640 (1007823) 1007823..1008563 + 741 WP_000779257.1 KDGP aldolase family protein -
PT747_RS04645 (1008580) 1008580..1010513 + 1934 Protein_893 BglG family transcription antiterminator -
PT747_RS04650 (1010591) 1010591..1010833 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PT747_RS04655 (1010823) 1010823..1011107 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT747_RS04660 (1011111) 1011111..1011575 - 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PT747_RS04665 (1011792) 1011792..1013930 - 2139 WP_001541406.1 anaerobic ribonucleoside-triphosphate reductase -
PT747_RS04670 (1014339) 1014339..1015987 - 1649 Protein_898 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T272621 WP_000220578.1 NZ_CP117976:1010823-1011107 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT272621 WP_000212724.1 NZ_CP117976:1010591-1010833 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References