Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 197163..197923 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PT747_RS00830 Protein ID WP_000533909.1
Coordinates 197163..197648 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PT747_RS00835 Protein ID WP_000965886.1
Coordinates 197636..197923 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS00805 (192825) 192825..193535 - 711 WP_001541097.1 DUF3053 domain-containing protein -
PT747_RS00810 (193974) 193974..194264 + 291 WP_000455790.1 HTH-type transcriptional regulator -
PT747_RS00815 (194552) 194552..194764 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PT747_RS00820 (194938) 194938..195477 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
PT747_RS00825 (195729) 195729..196984 + 1256 WP_110301500.1 IS3-like element ISSen1 family transposase -
PT747_RS00830 (197163) 197163..197648 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PT747_RS00835 (197636) 197636..197923 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PT747_RS00840 (198101) 198101..198568 - 468 WP_000702450.1 GNAT family N-acetyltransferase -
PT747_RS00845 (198740) 198740..199141 - 402 Protein_166 IS3 family transposase -
PT747_RS00850 (199403) 199403..201472 - 2070 WP_001291737.1 glycine--tRNA ligase subunit beta -
PT747_RS00855 (201482) 201482..202393 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PT747_RS00860 (202532) 202532..202834 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T272619 WP_000533909.1 NZ_CP117976:c197648-197163 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT272619 WP_000965886.1 NZ_CP117976:c197923-197636 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References