Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 87222..88013 Replicon chromosome
Accession NZ_CP117976
Organism Salmonella enterica strain B-4212

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag PT747_RS00360 Protein ID WP_000369560.1
Coordinates 87222..87740 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag PT747_RS00365 Protein ID WP_001275017.1
Coordinates 87744..88013 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT747_RS00335 (82293) 82293..83060 - 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PT747_RS00340 (83057) 83057..84334 - 1278 WP_001541045.1 branched chain amino acid ABC transporter permease LivM -
PT747_RS00345 (84331) 84331..85257 - 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PT747_RS00350 (85317) 85317..86420 - 1104 WP_023235350.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PT747_RS00355 (86842) 86842..87225 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
PT747_RS00360 (87222) 87222..87740 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
PT747_RS00365 (87744) 87744..88013 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
PT747_RS00370 (88191) 88191..89294 - 1104 WP_001535347.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PT747_RS00375 (89616) 89616..90470 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
PT747_RS00380 (90716) 90716..91771 - 1056 WP_001079363.1 permease-like cell division protein FtsX -
PT747_RS00385 (91764) 91764..92432 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T272618 WP_000369560.1 NZ_CP117976:c87740-87222 [Salmonella enterica]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT272618 WP_001275017.1 NZ_CP117976:c88013-87744 [Salmonella enterica]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References