272616

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6819433..6820019 Replicon chromosome
Accession NZ_CP117974
Organism Pseudomonas aeruginosa strain B-3509

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PT746_RS32320 Protein ID WP_003120987.1
Coordinates 6819433..6819732 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PT746_RS32325 Protein ID WP_003448662.1
Coordinates 6819729..6820019 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT746_RS32300 6814546..6815079 - 534 WP_003099760.1 type IV pilus biogenesis protein PilP -
PT746_RS32305 6815069..6816394 - 1326 WP_003099758.1 type 4b pilus protein PilO2 -
PT746_RS32310 6816398..6818107 - 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
PT746_RS32315 6818107..6819231 - 1125 WP_012076859.1 TcpQ domain-containing protein -
PT746_RS32320 6819433..6819732 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT746_RS32325 6819729..6820019 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PT746_RS32330 6820090..6820434 - 345 WP_016851612.1 hypothetical protein -
PT746_RS32335 6820575..6822551 - 1977 WP_016851611.1 DEAD/DEAH box helicase -
PT746_RS32340 6822548..6824437 - 1890 WP_016851610.1 hypothetical protein -
PT746_RS32345 6824659..6824868 - 210 WP_003105733.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T272616 WP_003120987.1 NZ_CP117974:6819433-6819732 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT272616 WP_003448662.1 NZ_CP117974:6819729-6820019 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References