272614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5393463..5393968 Replicon chromosome
Accession NZ_CP117974
Organism Pseudomonas aeruginosa strain B-3509

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag PT746_RS25660 Protein ID WP_003121619.1
Coordinates 5393687..5393968 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag PT746_RS25655 Protein ID WP_003112628.1
Coordinates 5393463..5393690 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT746_RS25630 5388481..5389974 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
PT746_RS25635 5390143..5391570 + 1428 WP_003083784.1 GABA permease -
PT746_RS25640 5391652..5391993 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PT746_RS25645 5392066..5392566 - 501 WP_003101228.1 LEA type 2 family protein -
PT746_RS25650 5392667..5393287 + 621 WP_003101226.1 hypothetical protein -
PT746_RS25655 5393463..5393690 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
PT746_RS25660 5393687..5393968 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
PT746_RS25665 5394268..5395176 + 909 WP_003083769.1 LysR family transcriptional regulator -
PT746_RS25670 5395208..5395618 - 411 WP_003101225.1 aegerolysin family protein -
PT746_RS25675 5395798..5396532 - 735 WP_003117208.1 GntR family transcriptional regulator -
PT746_RS25680 5396633..5397319 - 687 WP_004351997.1 FadR/GntR family transcriptional regulator -
PT746_RS25685 5397368..5398717 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T272614 WP_003121619.1 NZ_CP117974:5393687-5393968 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT272614 WP_003112628.1 NZ_CP117974:5393463-5393690 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References