272611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1631067..1632288 Replicon chromosome
Accession NZ_CP117974
Organism Pseudomonas aeruginosa strain B-3509

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PT746_RS07710 Protein ID WP_003102740.1
Coordinates 1631067..1631645 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PT746_RS07715 Protein ID WP_003088112.1
Coordinates 1631734..1632288 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT746_RS07695 1626343..1627620 + 1278 WP_003102743.1 TolC family protein -
PT746_RS07700 1627610..1629781 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
PT746_RS07705 1629771..1630958 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PT746_RS07710 1631067..1631645 - 579 WP_003102740.1 HD domain-containing protein Toxin
PT746_RS07715 1631734..1632288 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PT746_RS07720 1632446..1634641 - 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PT746_RS07725 1634646..1635107 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PT746_RS07730 1635438..1635761 + 324 WP_003162861.1 multidrug efflux SMR transporter -
PT746_RS07735 1635774..1636172 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PT746_RS07740 1636169..1636720 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T272611 WP_003102740.1 NZ_CP117974:c1631645-1631067 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT272611 WP_003088112.1 NZ_CP117974:c1632288-1631734 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References