Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 700937..702195 Replicon chromosome
Accession NZ_CP117974
Organism Pseudomonas aeruginosa strain B-3509

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PT746_RS03320 Protein ID WP_003163133.1
Coordinates 701440..702195 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PT746_RS03315 Protein ID WP_003086329.1
Coordinates 700937..701305 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT746_RS03295 697100..697375 + 276 WP_023088486.1 zinc ribbon domain-containing protein -
PT746_RS03300 697378..697854 - 477 WP_004353334.1 elongation factor GreAB -
PT746_RS03305 698029..699522 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
PT746_RS03310 699578..700864 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
PT746_RS03315 700937..701305 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PT746_RS03320 701440..702195 + 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PT746_RS03325 702964..704325 + 1362 WP_073652223.1 DNA recombination protein RmuC -
PT746_RS03330 704480..707023 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T272610 WP_003163133.1 NZ_CP117974:701440-702195 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT272610 WP_003086329.1 NZ_CP117974:700937-701305 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References