Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 38291..39089 Replicon plasmid unnamed1
Accession NZ_CP117972
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag PT723_RS23775 Protein ID WP_000072677.1
Coordinates 38291..38812 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag PT723_RS23780 Protein ID WP_001351987.1
Coordinates 38820..39089 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS23755 35983..36765 + 783 WP_062873814.1 receptor-recognizing protein -
PT723_RS23760 36840..37163 + 324 WP_000064173.1 hypothetical protein -
PT723_RS23765 37177..37869 + 693 WP_032084069.1 membrane protein -
PT723_RS23770 37871..38122 + 252 WP_000901559.1 hypothetical protein -
PT723_RS23775 38291..38812 - 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
PT723_RS23780 38820..39089 - 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
PT723_RS23785 39408..40076 + 669 WP_000161229.1 AAA family ATPase -
PT723_RS23790 40082..40435 + 354 WP_162521425.1 hypothetical protein -
PT723_RS23795 40474..41151 - 678 WP_077883643.1 hypothetical protein -
PT723_RS23800 41530..42270 + 741 WP_062877884.1 hypothetical protein -
PT723_RS23805 42314..43654 + 1341 WP_000137333.1 DnaB-like helicase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120874 120874


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T272609 WP_000072677.1 NZ_CP117972:c38812-38291 [Escherichia coli]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT272609 WP_001351987.1 NZ_CP117972:c39089-38820 [Escherichia coli]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References