Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 4481268..4482082 | Replicon | chromosome |
| Accession | NZ_CP117971 | ||
| Organism | Escherichia coli strain B-1109 | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | S1PA82 |
| Locus tag | PT723_RS22030 | Protein ID | WP_001054376.1 |
| Coordinates | 4481268..4481525 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | B7MMJ3 |
| Locus tag | PT723_RS22035 | Protein ID | WP_001338189.1 |
| Coordinates | 4481537..4482082 (+) | Length | 182 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PT723_RS22005 (4476556) | 4476556..4477662 | + | 1107 | WP_001299704.1 | N-acetylneuraminate epimerase | - |
| PT723_RS22010 (4477727) | 4477727..4478707 | + | 981 | WP_000991455.1 | sialate O-acetylesterase | - |
| PT723_RS22015 (4478817) | 4478817..4479022 | + | 206 | Protein_4290 | HNH endonuclease | - |
| PT723_RS22020 (4479290) | 4479290..4480530 | - | 1241 | Protein_4291 | helicase YjhR | - |
| PT723_RS22025 (4480646) | 4480646..4480777 | + | 132 | WP_001309182.1 | hypothetical protein | - |
| PT723_RS22030 (4481268) | 4481268..4481525 | + | 258 | WP_001054376.1 | YjhX family toxin | Toxin |
| PT723_RS22035 (4481537) | 4481537..4482082 | + | 546 | WP_001338189.1 | N-acetyltransferase | Antitoxin |
| PT723_RS22040 (4482138) | 4482138..4482884 | + | 747 | WP_000354251.1 | class I SAM-dependent methyltransferase | - |
| PT723_RS22045 (4483053) | 4483053..4483271 | + | 219 | Protein_4296 | hypothetical protein | - |
| PT723_RS22050 (4483309) | 4483309..4483425 | + | 117 | Protein_4297 | VOC family protein | - |
| PT723_RS22055 (4483670) | 4483670..4484791 | + | 1122 | WP_000010829.1 | M42 family metallopeptidase | - |
| PT723_RS22060 (4484788) | 4484788..4485066 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB SgcB | - |
| PT723_RS22065 (4485078) | 4485078..4486391 | + | 1314 | WP_000460843.1 | PTS sugar transporter subunit IIC SgcC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimE / fimB | 4472692..4490306 | 17614 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T272608 WP_001054376.1 NZ_CP117971:4481268-4481525 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
Antitoxin
Download Length: 182 a.a. Molecular weight: 19986.92 Da Isoelectric Point: 6.3277
>AT272608 WP_001338189.1 NZ_CP117971:4481537-4482082 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1PA82 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2KXJ3 |