Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3922711..3923329 Replicon chromosome
Accession NZ_CP117971
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PT723_RS19370 Protein ID WP_001291435.1
Coordinates 3923111..3923329 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PT723_RS19365 Protein ID WP_000344800.1
Coordinates 3922711..3923085 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS19355 (3917800) 3917800..3918993 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PT723_RS19360 (3919016) 3919016..3922165 + 3150 WP_137044402.1 efflux RND transporter permease AcrB -
PT723_RS19365 (3922711) 3922711..3923085 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PT723_RS19370 (3923111) 3923111..3923329 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PT723_RS19375 (3923501) 3923501..3924052 + 552 WP_000102564.1 maltose O-acetyltransferase -
PT723_RS19380 (3924168) 3924168..3924638 + 471 WP_000136192.1 YlaC family protein -
PT723_RS19385 (3924802) 3924802..3926352 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PT723_RS19390 (3926394) 3926394..3926747 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PT723_RS19400 (3927126) 3927126..3927437 + 312 WP_000409911.1 MGMT family protein -
PT723_RS19405 (3927468) 3927468..3928040 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T272604 WP_001291435.1 NZ_CP117971:3923111-3923329 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT272604 WP_000344800.1 NZ_CP117971:3922711-3923085 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References