Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2748329..2748967 Replicon chromosome
Accession NZ_CP117971
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name hicA Uniprot ID A0A2X7GI71
Locus tag PT723_RS13315 Protein ID WP_032231106.1
Coordinates 2748791..2748967 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PT723_RS13310 Protein ID WP_001270286.1
Coordinates 2748329..2748745 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS13290 (2743481) 2743481..2744422 - 942 WP_001251313.1 ABC transporter permease -
PT723_RS13295 (2744423) 2744423..2745436 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PT723_RS13300 (2745454) 2745454..2746599 - 1146 WP_000047429.1 ABC transporter substrate-binding protein -
PT723_RS13305 (2746844) 2746844..2748250 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PT723_RS13310 (2748329) 2748329..2748745 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PT723_RS13315 (2748791) 2748791..2748967 - 177 WP_032231106.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PT723_RS13320 (2749189) 2749189..2749419 + 231 WP_000494244.1 YncJ family protein -
PT723_RS13325 (2749511) 2749511..2751472 - 1962 WP_001491066.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PT723_RS13330 (2751545) 2751545..2752081 - 537 WP_000429151.1 DNA-binding transcriptional regulator SutR -
PT723_RS13335 (2752173) 2752173..2753345 + 1173 WP_250881039.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6680.72 Da        Isoelectric Point: 10.9223

>T272602 WP_032231106.1 NZ_CP117971:c2748967-2748791 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPCHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT272602 WP_001270286.1 NZ_CP117971:c2748745-2748329 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7GI71

Antitoxin

Source ID Structure

References