Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1204251..1204905 Replicon chromosome
Accession NZ_CP117971
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PT723_RS05835 Protein ID WP_000244777.1
Coordinates 1204498..1204905 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PT723_RS05830 Protein ID WP_000354046.1
Coordinates 1204251..1204517 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS05805 (1199420) 1199420..1200163 + 744 WP_000951964.1 SDR family oxidoreductase -
PT723_RS05810 (1200220) 1200220..1201653 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
PT723_RS05815 (1201698) 1201698..1202009 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PT723_RS05820 (1202173) 1202173..1202832 + 660 WP_000250274.1 hemolysin III family protein -
PT723_RS05825 (1203028) 1203028..1204008 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PT723_RS05830 (1204251) 1204251..1204517 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PT723_RS05835 (1204498) 1204498..1204905 + 408 WP_000244777.1 protein YgfX Toxin
PT723_RS05840 (1204945) 1204945..1205466 - 522 WP_001055874.1 flavodoxin FldB -
PT723_RS05845 (1205578) 1205578..1206474 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PT723_RS05850 (1206499) 1206499..1207209 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PT723_RS05855 (1207215) 1207215..1208948 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T272593 WP_000244777.1 NZ_CP117971:1204498-1204905 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT272593 WP_000354046.1 NZ_CP117971:1204251-1204517 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References