272588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2804971..2806004 Replicon chromosome
Accession NZ_CP117970
Organism Enterococcus faecalis strain B-537

Toxin (Protein)


Gene name IrrE Uniprot ID R3K9G6
Locus tag PT722_RS13655 Protein ID WP_002365229.1
Coordinates 2805351..2806004 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag PT722_RS13650 Protein ID WP_002365228.1
Coordinates 2804971..2805354 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT722_RS13595 (2800800) 2800800..2801168 - 369 WP_002365216.1 DUF86 domain-containing protein -
PT722_RS13600 (2801152) 2801152..2801484 - 333 WP_002399122.1 nucleotidyltransferase domain-containing protein -
PT722_RS13605 (2801544) 2801544..2801867 - 324 WP_002399121.1 hypothetical protein -
PT722_RS13610 (2801907) 2801907..2802146 - 240 WP_002365219.1 hypothetical protein -
PT722_RS13615 (2802157) 2802157..2802309 - 153 WP_002365221.1 hypothetical protein -
PT722_RS13620 (2802336) 2802336..2802560 - 225 WP_002365222.1 hypothetical protein -
PT722_RS13625 (2802792) 2802792..2802980 + 189 WP_002365223.1 hypothetical protein -
PT722_RS13630 (2802967) 2802967..2803128 - 162 WP_002365224.1 hypothetical protein -
PT722_RS13635 (2803151) 2803151..2803567 - 417 WP_002365225.1 DUF961 family protein -
PT722_RS13640 (2803567) 2803567..2803893 - 327 WP_002365226.1 hypothetical protein -
PT722_RS13645 (2803979) 2803979..2804230 - 252 WP_002365227.1 hypothetical protein -
PT722_RS13650 (2804971) 2804971..2805354 + 384 WP_002365228.1 helix-turn-helix transcriptional regulator Antitoxin
PT722_RS13655 (2805351) 2805351..2806004 + 654 WP_002365229.1 ImmA/IrrE family metallo-endopeptidase Toxin
PT722_RS13660 (2806043) 2806043..2806378 + 336 WP_002365231.1 helix-turn-helix domain-containing protein -
PT722_RS13665 (2806416) 2806416..2807747 - 1332 WP_002365232.1 FAD-dependent oxidoreductase -
PT722_RS13670 (2807846) 2807846..2808781 - 936 WP_171803825.1 aldo/keto reductase -
PT722_RS13675 (2808796) 2808796..2809215 - 420 WP_002365234.1 MerR family transcriptional regulator -
PT722_RS13680 (2809232) 2809232..2809813 - 582 WP_002365235.1 histidine phosphatase family protein -
PT722_RS13685 (2810035) 2810035..2810364 + 330 WP_002365236.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 26065.01 Da        Isoelectric Point: 6.2394

>T272588 WP_002365229.1 NZ_CP117970:2805351-2806004 [Enterococcus faecalis]
MIGLLLVDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEVMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFAHANTLFNNYYFHKETDIYRFIFN

Download         Length: 654 bp

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 15032.03 Da        Isoelectric Point: 5.1063

>AT272588 WP_002365228.1 NZ_CP117970:2804971-2805354 [Enterococcus faecalis]
VQPLAKRLQLLREEKEWTKTYVAKQLGLNNLGTYANWEYGTREPDSEMLSKIASLYDVSTDFLLGRTEERIHLNDKEKIG
KNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKN

Download         Length: 384 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3K9G6

Antitoxin

Source ID Structure

References