Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1746488..1747125 Replicon chromosome
Accession NZ_CP117967
Organism Veillonella rogosae strain AC2811 AN NA

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PT376_RS08190 Protein ID WP_274204420.1
Coordinates 1746715..1747125 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C4FMM5
Locus tag PT376_RS08185 Protein ID WP_005384838.1
Coordinates 1746488..1746718 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT376_RS08175 1743888..1744745 + 858 WP_274205222.1 methylenetetrahydrofolate reductase -
PT376_RS08180 1745043..1745795 - 753 WP_274204419.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
PT376_RS08185 1746488..1746718 + 231 WP_005384838.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PT376_RS08190 1746715..1747125 + 411 WP_274204420.1 type II toxin-antitoxin system VapC family toxin Toxin
PT376_RS08195 1747201..1749072 - 1872 WP_274204421.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG -
PT376_RS08200 1749420..1750805 - 1386 WP_274204422.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
PT376_RS08205 1751058..1751858 - 801 WP_274204423.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(9-44)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15323.74 Da        Isoelectric Point: 6.6380

>T272570 WP_274204420.1 NZ_CP117967:1746715-1747125 [Veillonella rogosae]
MKYMLDTNICIYAIKQEPEVVLQKILKHHPSDICISSITYAELMHGVEKSQSKDKNRLALTLLLSPIQIVDFDSHTAEEY
GKIKADLQSQGKVIGPMDLLIASHAKSKGLTIVTNNTKEFERVTQLEVEDWSKPLS

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8660.82 Da        Isoelectric Point: 4.4217

>AT272570 WP_005384838.1 NZ_CP117967:1746488-1746718 [Veillonella rogosae]
MTTAKLFENGRSQAVRLPKEFRFNGDEVIINKIGNVVLLMPKDDEWAGFVAGLSLFTDDFMCNGREDIDHQEREAL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S7YY19

References