Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2097717..2098426 Replicon chromosome
Accession NZ_CP117963
Organism Faecalibacterium prausnitzii strain AP34BHI

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PT301_RS10150 Protein ID WP_118551954.1
Coordinates 2097717..2097908 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PT301_RS10155 Protein ID WP_118551952.1
Coordinates 2098049..2098426 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT301_RS10130 2092890..2095010 - 2121 WP_118551960.1 ribonuclease R -
PT301_RS10135 2095244..2095492 - 249 WP_097792492.1 preprotein translocase subunit SecG -
PT301_RS10140 2095592..2097181 - 1590 WP_118551958.1 penicillin-binding transpeptidase domain-containing protein -
PT301_RS10145 2097335..2097604 + 270 WP_270476948.1 helix-turn-helix transcriptional regulator -
PT301_RS10150 2097717..2097908 + 192 WP_118551954.1 type II toxin-antitoxin system HicA family toxin Toxin
PT301_RS10155 2098049..2098426 + 378 WP_118551952.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PT301_RS10160 2098511..2099461 - 951 WP_118551950.1 hypothetical protein -
PT301_RS10165 2099478..2100473 - 996 WP_118551948.1 DUF4065 domain-containing protein -
PT301_RS10170 2100761..2102404 - 1644 WP_118551946.1 chaperonin GroEL -
PT301_RS10175 2102455..2102742 - 288 WP_055187788.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2092890..2102742 9852
- inside Prophage - groEL 2088779..2102742 13963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-114)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7076.31 Da        Isoelectric Point: 10.6709

>T272564 WP_118551954.1 NZ_CP117963:2097717-2097908 [Faecalibacterium prausnitzii]
MPMTPKQMIRLLEQNGFVLVSANGSHYKYHNPTTNQTTVVPFHAKDLKPGTEKNILKLAGLKK

Download         Length: 192 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14016.96 Da        Isoelectric Point: 4.1445

>AT272564 WP_118551952.1 NZ_CP117963:2098049-2098426 [Faecalibacterium prausnitzii]
MNAIFYPAIFHPEETGYSVEIPDIEGCFTQGDTMDEAVRMAQDAIGLMLEDCKVCPEPSIPSALHVDPEDFVVMVPFDME
EYEKRYRPVKKTLSIPGWLNDAAESAHINFSGVLQDALKEKLHLA

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References